Almonertinib mesylate ( HS-10296 mesylate )

Catalog No. M28940 CAS No. 2134096-06-1

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Product Name

Almonertinib mesylate
Note

Research use only, not for human use.
Brief Description

Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer studies.
Description

Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer studies.(In Vitro):Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q.
Synonyms

HS-10296 mesylate
Pathway

Angiogenesis
Target

EGFR
Recptor

Na+ channel
Research Area

——
Indication

——

CAS Number

2134096-06-1
Formula Weight

621.8
Molecular Formula

C31H39N7O5S
Purity

>98% (HPLC)
Solubility

——
SMILES

C=CC(NC1=CC(NC2=NC=CC(C3=CN(C4CC4)C5=C3C=CC=C5)=N2)=C(OC)C=C1N(CCN(C)C)C)=O.CS(=O)(O)=O
Chemical Name

——

1.Jean-Christophe ANDREZ, et al. Benzenesulfonamide compounds and their use as therapeutic agents. Patent WO2017201468A1.

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